γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice

生物 病毒 获得性免疫系统 免疫系统 病毒学 过继性细胞移植 CD8型 免疫 免疫学 T细胞
作者
Tian Wang,Yunfei Gao,Eileen P. Scully,C. Todd Davis,John F. Anderson,Thomas Welte,Michel Ledizet,Raymond A. Koski,Joseph A. Madri,Alan D.T. Barrett,Zhinan Yin,Joseph Craft,Erol Fikrig
出处
期刊:Journal of Immunology [The American Association of Immunologists]
卷期号:177 (3): 1825-1832 被引量:84
标识
DOI:10.4049/jimmunol.177.3.1825
摘要

Abstract West Nile (WN) virus causes fatal meningoencephalitis in laboratory mice, and γδ T cells are involved in the protective immune response against viral challenge. We have now examined whether γδ T cells contribute to the development of adaptive immune responses that help control WN virus infection. Approximately 15% of TCRδ−/− mice survived primary infection with WN virus compared with 80–85% of the wild-type mice. These mice were more susceptible to secondary challenge with WN virus than the wild-type mice that survived primary challenge with the virus. Depletion of γδ T cells in wild-type mice that survived the primary infection, however, does not affect host susceptibility during secondary challenge with WN virus. Furthermore, γδ T cells do not influence the development of Ab responses during primary and at the early stages of secondary infection with WN virus. Adoptive transfer of CD8+ T cells from wild-type mice that survived primary infection with WN virus to naive mice afforded partial protection from lethal infection. In contrast, transfer of CD8+ T cells from TCRδ−/− mice that survived primary challenge with WN virus failed to alter infection in naive mice. This difference in survival correlated with the numeric and functional reduction of CD8 memory T cells in these mice. These data demonstrate that γδ T cells directly link innate and adaptive immunity during WN virus infection.
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