西斯特
基因沉默
核板
生物
X-失活
遗传学
长非编码RNA
细胞生物学
X染色体
核糖核酸
基因
转录因子
核蛋白
作者
Chun-Kan Chen,Mario R. Blanco,Constanza Jackson,Erik Aznauryan,Noah Ollikainen,Christine Surka,Amy Chow,Andrea Cerase,Patrick McDonel,Mitchell Guttman
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-08-05
卷期号:354 (6311): 468-472
被引量:258
标识
DOI:10.1126/science.aae0047
摘要
The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome. Yet, it remains unclear whether these changes in nuclear structure are mediated by Xist and whether they are required for silencing. Here, we show that Xist directly interacts with the Lamin B receptor, an integral component of the nuclear lamina, and that this interaction is required for Xist-mediated silencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to actively transcribed genes across the X. Our results demonstrate that lamina recruitment changes the 3D structure of DNA, enabling Xist and its silencing proteins to spread across the X to silence transcription.
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