肠促胰岛素
背景(考古学)
医学
糖尿病
葡萄糖稳态
内分泌学
肽YY
2型糖尿病
内科学
减肥
激素
肥胖
胰岛素抵抗
生物
受体
神经肽
古生物学
神经肽Y受体
作者
Claudia Guida,Sam D. Stephen,Romain Guitton,Reshma Ramracheya
标识
DOI:10.1016/j.tem.2017.04.005
摘要
Bariatric surgery in obese individuals leads to rapid and lasting remission of type 2 diabetes (T2D). This phenomenon occurs independently of weight loss possibly via a combination of factors. The incretin hormone GLP-1 has so far been recognised as a critical factor. However, recent data have indicated that elevation in another gut hormone, peptide tyrosine tyrosine (PYY), may drive the beneficial effects of surgery. Here we discuss recent findings on PYY-mediated control of glucose homeostasis and its role in diabetes, in the context of what is known for GLP-1. Identification of factors that increase the expression of PYY following bariatric surgery and elucidation of its role in diabetes reversal may have clinical relevance as a nonsurgical therapy for T2D.
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