化学
烷基
布朗斯特德-洛瑞酸碱理论
芳基
劈理(地质)
键裂
催化作用
组合化学
药物化学
立体化学
有机化学
断裂(地质)
工程类
岩土工程
作者
Yanzhong Li,Yulei Zhao,Yang Yuan,Lingkai Kong,Fangfang Zhang
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2017-05-09
卷期号:49 (16): 3609-3618
被引量:5
标识
DOI:10.1055/s-0036-1588820
摘要
A novel gold(I)/Brønsted acid sequential catalyzed/promoted procedure to synthesize 1-alkyl-3-(2-oxo-2-aryl/alkyl-ethyl)indolin-2-ones under mild reaction conditions is developed. This methodology is realized by relay actions of gold and a Brønsted acid in a one-pot multistep manner. The gold(I)-catalyzed chemoselective C(sp2)-H functionalization of enaminones and Brønsted acid promoted cleavage of the C=C bond are integrated effectively. Based on the results of control experiments and ESI-MS analysis, a possible reaction mechanism is proposed.
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