肌萎缩
生物标志物
生物标志物发现
还原论
鉴定(生物学)
多元统计
肌肉团
医学
计算机科学
老年学
数据科学
蛋白质组学
生物
机器学习
内科学
哲学
认识论
基因
植物
生物化学
作者
Riccardo Calvani,Anna Picca,Matteo Cesari,Matteo Tosato,Federico Marini,Ester Manes-Gravina,Roberto Bernabei,Francesco Landi,Emanuele Marzetti
出处
期刊:Current Protein & Peptide Science
[Bentham Science Publishers]
日期:2017-05-19
卷期号:19 (7): 639-642
被引量:20
标识
DOI:10.2174/1389203718666170516115422
摘要
Sarcopenia, the progressive and generalized loss of muscle mass and strength/function, is a major health issue in older adults, given its high prevalence and burdensome clinical ramifications. The absence of a unified operational definition for sarcopenia has hampered its full appreciation by healthcare providers, researchers and policy-makers. At the same time, this unresolved debate and the complexity of musculoskeletal aging pose major challenges to the identification of clinically meaningful biomarkers. This review summarizes the current knowledge on biological markers for sarcopenia, including a critical appraisal of traditional procedures for biomarker development in the field of muscle aging. As an alternative approach, we illustrate the potential advantages of biomarker discovery procedures based on multivariate methodologies. Relevant examples of multidimensional biomarker modeling are provided with an emphasis on its clinical and research application. Keywords: Frailty, physical performance, markers, multivariate analysis, skeletal muscle, disability.
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