纳米棒
硼氢化钠
X射线光电子能谱
溴化物
试剂
拉曼光谱
材料科学
化学工程
傅里叶变换红外光谱
表面增强拉曼光谱
还原剂
纳米技术
胶体金
核化学
化学
纳米颗粒
无机化学
有机化学
拉曼散射
催化作用
工程类
光学
物理
作者
Jie He,Sarah Unser,Ian Bruzas,ReJeana Cary,Zhiwei Shi,Rajesh Mehra,Kenneth Aron,Laura Sagle
标识
DOI:10.1016/j.colsurfb.2017.12.019
摘要
A common capping agent for gold nanorods, Cetyl trimethylammonium bromide (CTAB), is particularly problematic for biological studies because of its cytotoxicity. Several procedures have been developed to remove the CTAB from the surface of the gold nanorods, but most are lengthy, involving many steps, and use expensive reagents. Here, we present a simple, one-pot method for the complete removal of CTAB from the surface of gold nanorods, so that particles can be more effectively utilized in biological in vivo studies. The procedure involves first adding sodium borohydride to remove the CTAB, quickly followed by a replacement ligand, such as mercaptoundecanoic acid (MUA). Both the CTAB removal and MUA replacement were monitored by FTIR, surface enhanced Raman spectroscopy (SERS) and X-Ray Photoelectron Spectroscopy (XPS) and compared to commercially available citrate-capped gold nanorods. The procedure presented herein is shown to be as effective at removing CTAB and replacing it with MUA as commercially available gold nanorod samples.
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