聚合物囊泡
超氧化物歧化酶
抗氧化剂
神经病理性疼痛
体内
水溶液
药理学
化学
材料科学
生物化学
医学
有机化学
共聚物
生物
聚合物
两亲性
生物技术
作者
Sonia Kartha,Lesan Yan,Christine L. Weisshaar,Meagan Ita,Vladimir V. Shuvaev,Vladimir R. Muzykantov,Andrew Tsourkas,Beth A. Winkelstein,Zhiliang Cheng
标识
DOI:10.1002/adhm.201700500
摘要
A highly efficient antioxidant is developed by encapsulating superoxide dismutase (SOD) within the aqueous interior of porous polymersomes. The porous polymersomes provide a permeable membrane that allows free superoxide radicals to pass into the aqueous interior and interact with the encapsulated antioxidant enzyme SOD. In vivo studies in the rat demonstrate that administration of SOD‐encapsulated porous polymersomes can prevent neuropathic pain after nerve root compression more effectively than treatment with free antioxidant enzyme alone.
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