党参
果聚糖
菊粉
胃肠病学
免疫系统
胃炎
医学
胃粘膜
传统医学
化学
内科学
中医药
药理学
胃
免疫学
食品科学
病理
替代医学
蔗糖
作者
Jiankuan Li,Tao Wang,Zhichuan Zhu,Fengrong Yang,Lingya Cao,Jianping Gao
出处
期刊:Molecules
[MDPI AG]
日期:2017-12-18
卷期号:22 (12): 2258-2258
被引量:61
标识
DOI:10.3390/molecules22122258
摘要
Radix Codonopsis has been used in traditional Chinese medicine for strengthening the immune system, improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis and so on. In the present study, an inulin-type fructan CP-A was obtained from the roots of Codonopsis pilosula (Franch.) Nannf. and its structure was confirmed by MS and NMR as (2 → 1) linked-β-d-fructofuranose. The protective effects of CP-A against ethanol-induced acute gastric ulcer in rats were intensively investigated. A Lacy assay demonstrated that CP-A-treated group (50 mg/kg) showed the gastric damage level 1, which was similar to the positive control group, while the model group exhibited the gastric damage level 3. The Guth assay demonstrated that the mucosa ulcer index for CP-A groups at the doses of 50 mg/kg and 25 mg/kg significantly decreased compared with that in the model group (p < 0.05). Meanwhile, CP-A significantly increased the activities of SOD and GSH-Px, and decreased the contents of MDA and NO, and the activity of MPO in gastric tissue in a dose-dependent manner (p < 0.05). The present research reported for the first time that inulin-type fructan CP-A were likely the potential component in Radix Codonopsis for treatment of acute gastric ulcers.
科研通智能强力驱动
Strongly Powered by AbleSci AI