后代
产前应激
神经认知
怀孕
心理学
压力源
妊娠期
性情
发展心理学
认知
神经科学
生物
遗传学
社会心理学
人格
作者
Bea Van den Bergh,Marion I. van den Heuvel,Marius Lahti‐Pulkkinen,Marijke Braeken,Susanne R. de Rooij,Sonja Entringer,Dirk Hoyer,Tessa J. Roseboom,Katri Räikkönen,Suzanne King,Matthias Schwab
标识
DOI:10.1016/j.neubiorev.2017.07.003
摘要
Accumulating research shows that prenatal exposure to maternal stress increases the risk for behavioral and mental health problems later in life. This review systematically analyzes the available human studies to identify harmful stressors, vulnerable periods during pregnancy, specificities in the outcome and biological correlates of the relation between maternal stress and offspring outcome. Effects of maternal stress on offspring neurodevelopment, cognitive development, negative affectivity, difficult temperament and psychiatric disorders are shown in numerous epidemiological and case-control studies. Offspring of both sexes are susceptible to prenatal stress but effects differ. There is not any specific vulnerable period of gestation; prenatal stress effects vary for different gestational ages possibly depending on the developmental stage of specific brain areas and circuits, stress system and immune system. Biological correlates in the prenatally stressed offspring are: aberrations in neurodevelopment, neurocognitive function, cerebral processing, functional and structural brain connectivity involving amygdalae and (pre)frontal cortex, changes in hypothalamo-pituitary-adrenal (HPA)-axis and autonomous nervous system.
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