Inflammation in Cardiovascular Disease

n this issue of Circulation, Ridker and colleagues 1 discuss the incremental value of CRP as a predictor of future CVD events.Their conclusion is that CRP is at least additive to HDL and total cholesterol with respect to risk prediction.In fact, there is some evidence that lipids and CRP are better predictors jointly than would be expected by adding up their individual predictive powers.CRP appeared to predict events in those at low risk on the basis of lipids, and CRP-lipid relationships to events were minimally altered by adjustment for other known CVD risk factors.These findings have important implications for CVD risk assessment and risk management.