The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study

医学 糖尿病 入射(几何) 心理干预 危险系数 2型糖尿病 累积发病率 物理疗法 糖耐量受损 老年学 内科学 置信区间 内分泌学 移植 物理 光学 精神科
作者
Guangwei Li,Ping Zhang,Jinping Wang,Edward W. Gregg,Wenying Yang,Qiuhong Gong,Hui Li,Hongliang Li,Jiang Yayun,Yali An,Ying Shuai,Bo Zhang,Jingling Zhang,Theodore J. Thompson,Robert B. Gerzoff,Gojka Roglić,Yinghua Hu,Peter H. Bennett
出处
期刊:The Lancet [Elsevier BV]
卷期号:371 (9626): 1783-1789 被引量:1548
标识
DOI:10.1016/s0140-6736(08)60766-7
摘要

Summary

Background

Intensive lifestyle interventions can reduce the incidence of type 2 diabetes in people with impaired glucose tolerance, but how long these benefits extend beyond the period of active intervention, and whether such interventions reduce the risk of cardiovascular disease (CVD) and mortality, is unclear. We aimed to assess whether intensive lifestyle interventions have a long-term effect on the risk of diabetes, diabetes-related macrovascular and microvascular complications, and mortality.

Methods

In 1986, 577 adults with impaired glucose tolerance from 33 clinics in China were randomly assigned to either the control group or to one of three lifestyle intervention groups (diet, exercise, or diet plus exercise). Active intervention took place over 6 years until 1992. In 2006, study participants were followed-up to assess the long-term effect of the interventions. The primary outcomes were diabetes incidence, CVD incidence and mortality, and all-cause mortality.

Findings

Compared with control participants, those in the combined lifestyle intervention groups had a 51% lower incidence of diabetes (hazard rate ratio [HRR] 0·49; 95% CI 0·33–0·73) during the active intervention period and a 43% lower incidence (0·57; 0·41–0·81) over the 20 year period, controlled for age and clustering by clinic. The average annual incidence of diabetes was 7% for intervention participants versus 11% in control participants, with 20-year cumulative incidence of 80% in the intervention groups and 93% in the control group. Participants in the intervention group spent an average of 3·6 fewer years with diabetes than those in the control group. There was no significant difference between the intervention and control groups in the rate of first CVD events (HRR 0·98; 95% CI 0·71–1·37), CVD mortality (0·83; 0·48–1·40), and all-cause mortality (0·96; 0·65–1·41), but our study had limited statistical power to detect differences for these outcomes.

Interpretation

Group-based lifestyle interventions over 6 years can prevent or delay diabetes for up to 14 years after the active intervention. However, whether lifestyle intervention also leads to reduced CVD and mortality remains unclear.

Funding

Centers for Disease Control and Prevention, WHO, the China-Japan Friendship Hospital, and Da Qing First Hospital.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
LIUYONG发布了新的文献求助10
刚刚
刚刚
肖雪依完成签到,获得积分10
刚刚
影子完成签到,获得积分10
1秒前
2秒前
晨珂完成签到,获得积分10
2秒前
Florencia发布了新的文献求助10
4秒前
xiezhuochun发布了新的文献求助10
5秒前
5秒前
同瓜不同命完成签到,获得积分10
7秒前
牛马哥发布了新的文献求助10
8秒前
温婉的松鼠完成签到,获得积分10
8秒前
9秒前
辛勤的寄瑶完成签到,获得积分10
9秒前
Lauren完成签到 ,获得积分10
10秒前
11秒前
忆枫完成签到,获得积分10
15秒前
炒鸡小将发布了新的文献求助10
15秒前
花壳在逃野猪完成签到 ,获得积分10
15秒前
15秒前
银子吃好的完成签到,获得积分10
16秒前
西瓜霜完成签到 ,获得积分10
16秒前
科研废物完成签到 ,获得积分10
18秒前
冬月完成签到,获得积分10
18秒前
18秒前
马东完成签到,获得积分10
20秒前
搜集达人应助动听的秋白采纳,获得10
20秒前
21秒前
量子星尘发布了新的文献求助10
21秒前
华仔应助炒鸡小将采纳,获得10
22秒前
chizhi完成签到,获得积分10
22秒前
雪雨夜心应助白智妍采纳,获得10
23秒前
祁乐安发布了新的文献求助20
24秒前
fang应助科研通管家采纳,获得10
25秒前
梵高的向日葵完成签到,获得积分10
25秒前
Singularity应助科研通管家采纳,获得10
25秒前
清爽的碧空完成签到,获得积分10
25秒前
天天快乐应助科研通管家采纳,获得10
25秒前
顾矜应助科研通管家采纳,获得10
25秒前
脑洞疼应助科研通管家采纳,获得10
25秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038303
求助须知:如何正确求助?哪些是违规求助? 3576013
关于积分的说明 11374210
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029