Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

扁桃形结构 益生菌 情绪障碍 肠-脑轴 心理学 心情 单胺类神经递质 行为绝望测验 肠道菌群 内科学 饮食失调 内分泌学 医学 神经科学 免疫学 焦虑 生物 临床心理学 精神科 血清素 受体 细菌 抗抑郁药 遗传学
作者
Lieve Desbonnet,Lillian Garrett,Gerard Clarke,Barry Kiely,John F. Cryan,Timothy G. Dinan
出处
期刊:Neuroscience [Elsevier]
卷期号:170 (4): 1179-1188 被引量:797
标识
DOI:10.1016/j.neuroscience.2010.08.005
摘要

The concept that intestinal microbial composition not only affects the health of the gut, but also influences centrally-mediated systems involved in mood, is supported by a growing body of literature. Despite the emergent interest in brain-gut communication and its possible role in the pathogenesis of psychiatric disorders such as depression, particularly subtypes with accompanying gastrointestinal (GI) symptoms, there are few studies dedicated to the search for therapeutic solutions that address both central and peripheral facets of these illnesses. This study aims to assess the potential benefits of the probiotic Bifidobacterium infantis in the rat maternal separation (MS) model, a paradigm that has proven to be of value in the study of stress-related GI and mood disorders. MS adult rat offsprings were chronically treated with bifidobacteria or citalopram and subjected to the forced swim test (FST) to assess motivational state. Cytokine concentrations in stimulated whole blood samples, monoamine levels in the brain, and central and peripheral hypothalamic-pituitary-adrenal (HPA) axis measures were also analysed. MS reduced swim behavior and increased immobility in the FST, decreased noradrenaline (NA) content in the brain, and enhanced peripheral interleukin (IL)-6 release and amygdala corticotrophin-releasing factor mRNA levels. Probiotic treatment resulted in normalization of the immune response, reversal of behavioral deficits, and restoration of basal NA concentrations in the brainstem. These findings point to a more influential role for bifidobacteria in neural function, and suggest that probiotics may have broader therapeutic applications than previously considered.
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