断奶
二甲基肼
内科学
致癌物
发育不良
1,2-二甲基肼
溃疡性结肠炎
医学
结直肠癌
胃肠病学
入射(几何)
癌症
内分泌学
生理学
生物
疾病
生物化学
物理
光学
作者
Marília Cravo,Joel B. Mason,Yogeshwar Dayal,Martha L. Hutchinson,Donald E. Smith,Jacob Selhub,Irwin H. Rosenberg
出处
期刊:PubMed
日期:1992-09-15
卷期号:52 (18): 5002-6
被引量:132
摘要
In patients with ulcerative colitis, epidemiological work has suggested an association between low folate status and an increased risk of colonic neoplasia. The aim of the present study was to determine if experimental folate deficiency increases the likelihood of developing neoplasia in rats treated with the carcinogen dimethylhydrazine. Weanling male Sprague-Dawley rats were fed with an amino acid-defined diet containing either 8 or 0 mg/kg folic acid. After 5 weeks of defined diet, weekly s.c. injections of dimethylhydrazine (20 mg/kg) were administered to both groups. Serum, whole blood, liver, and colonic folate concentrations at the time of sacrifice were significantly lower in folate-depleted animals (P less than 0.001). There were significant differences in the incidence of colonic neoplasia between the two groups after 20 weeks of dimethylhydrazine exposure: folate-deficient rats had a greater incidence of dysplasia (6 of 7 versus 2 of 7 animals; P less than 0.05) and carcinoma (6 of 7 versus 1 of 7 animals; P less than 0.01). Furthermore, a significantly greater proportion of folate-replete rats than folate-deficient rats were free of neoplastic lesions (5 of 7 versus 0 of 7 animals; P less than 0.05). These results suggest that, in this animal model, folate deficiency increases the risk of malignancy when there is an underlying predisposition to colorectal cancer.
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