A dual-emissive-materials design concept enables tumour hypoxia imaging

磷光 荧光 材料科学 光化学 发光 聚合物 纳米技术 化学 光电子学 光学 物理 复合材料
作者
Guoqing Zhang,Gregory M. Palmer,Mark W. Dewhirst,Cassandra L. Fraser
出处
期刊:Nature Materials [Nature Portfolio]
卷期号:8 (9): 747-751 被引量:1046
标识
DOI:10.1038/nmat2509
摘要

Luminescent materials are widely used for imaging and sensing because of their high sensitivity and rapid response. A strategy for modulating dual emission for radiometric sensing in a single component is now shown to enable tumour hypoxia imaging. Luminescent materials are widely used for imaging and sensing owing to their high sensitivity, rapid response and facile detection by many optical technologies1. Typically materials must be chemically tailored to achieve intense, photostable fluorescence, oxygen-sensitive phosphorescence or dual emission for ratiometric sensing, often by blending two dyes in a matrix. Dual-emissive materials combining all of these features in one easily tunable molecular platform are desirable, but when fluorescence and phosphorescence originate from the same dye, it can be challenging to vary relative fluorescence/phosphorescence intensities for practical sensing applications. Heavy-atom substitution2 alone increases phosphorescence by a given, not variable amount. Here, we report a strategy for modulating fluorescence/phosphorescence for a single-component, dual-emissive, iodide-substituted difluoroboron dibenzoylmethane-poly(lactic acid) (BF2dbm(I)PLA) solid-state sensor material. This is accomplished through systematic variation of the PLA chain length in controlled solvent-free lactide polymerization3 combined with heavy-atom substitution2. We demonstrate the versatility of this approach by showing that films made from low-molecular-weight BF2dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ‘turn on’ sensors for aerodynamics applications4, and that nanoparticles fabricated from a higher-molecular-weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
简单灵凡发布了新的文献求助10
刚刚
出门见喜发布了新的文献求助10
刚刚
感谢张茜转发科研通微信,获得积分50
2秒前
芒果与鱼完成签到,获得积分10
3秒前
不再褪色发布了新的文献求助10
3秒前
purplemoon发布了新的文献求助10
3秒前
高高可乐发布了新的文献求助20
3秒前
4秒前
5秒前
5秒前
感谢WU转发科研通微信,获得积分50
5秒前
wanci应助小明同学采纳,获得10
6秒前
彭于晏应助出门见喜采纳,获得10
6秒前
潘森爱科研完成签到,获得积分10
6秒前
6秒前
7秒前
smile完成签到,获得积分10
7秒前
顾矜应助酱er采纳,获得30
7秒前
简单灵凡完成签到,获得积分10
7秒前
fjh应助科研通管家采纳,获得10
8秒前
bkagyin应助科研通管家采纳,获得10
8秒前
8秒前
科研通AI5应助科研通管家采纳,获得10
8秒前
充电宝应助科研通管家采纳,获得10
8秒前
FashionBoy应助科研通管家采纳,获得10
8秒前
科目三应助科研通管家采纳,获得10
9秒前
9秒前
斯文败类应助科研通管家采纳,获得10
9秒前
感谢666转发科研通微信,获得积分50
9秒前
wanci应助科研通管家采纳,获得10
9秒前
听话的画板完成签到,获得积分20
9秒前
9秒前
机智若枫发布了新的文献求助10
9秒前
9秒前
9秒前
9秒前
9秒前
9秒前
9秒前
zzz发布了新的文献求助10
10秒前
高分求助中
All the Birds of the World 4000
Production Logging: Theoretical and Interpretive Elements 3000
Les Mantodea de Guyane Insecta, Polyneoptera 2000
Am Rande der Geschichte : mein Leben in China / Ruth Weiss 1500
CENTRAL BOOKS: A BRIEF HISTORY 1939 TO 1999 by Dave Cope 1000
Machine Learning Methods in Geoscience 1000
Resilience of a Nation: A History of the Military in Rwanda 888
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3737633
求助须知:如何正确求助?哪些是违规求助? 3281316
关于积分的说明 10024435
捐赠科研通 2998032
什么是DOI,文献DOI怎么找? 1645003
邀请新用户注册赠送积分活动 782459
科研通“疑难数据库(出版商)”最低求助积分说明 749814