药品
新陈代谢
药物代谢
化学
氟
药理学
生物化学
医学
有机化学
作者
B K Park,Neil R. Kitteringham,Paul M. O’Neill
出处
期刊：Annual Review of Pharmacology and Toxicology
[Annual Reviews]
日期：2001-04-01
卷期号：41 (1): 443-470
被引量：539
标识
DOI：10.1146/annurev.pharmtox.41.1.443
摘要
This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.
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