Wnt信号通路
生物
癌症干细胞
肝癌
癌症研究
转录组
干细胞
细胞生物学
长非编码RNA
信号转导
肝细胞癌
癌变
小RNA
癌症
核糖核酸
遗传学
基因表达
基因
作者
Yanying Wang,Lei He,Ying Du,Pingping Zhu,Guanling Huang,Jianjun Luo,Xinlong Yan,Buqing Ye,Chong Li,Pengyan Xia,Geng Zhang,Yong Tian,Di Wu,Zusen Fan
出处
期刊:Cell Stem Cell
[Elsevier]
日期:2015-04-02
卷期号:16 (4): 413-425
被引量:450
标识
DOI:10.1016/j.stem.2015.03.003
摘要
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to both of these pathological properties, but the mechanisms underlying their self-renewal and maintenance are poorly understood. Here, using transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed lncTCF7 that is highly expressed in HCC tumors and liver CSCs. LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that lncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. In sum, therefore, we have identified an lncRNA-based Wnt signaling regulatory circuit that promotes tumorigenic activity in liver cancer stem cells, highlighting the role that lncRNAs can play in tumor growth and propagation.
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