医学
冲程(发动机)
安慰剂
康复
临床试验
中风恢复
物理疗法
功能独立性测度
随机对照试验
子群分析
内科学
置信区间
替代医学
机械工程
工程类
病理
作者
Keng He Kong,Seng Kwee Wee,Chee Kwan Ng,Karen Sui Geok Chua,Kay Fei Chan,Narayanaswamy Venketasubramanian,Christopher Chen
出处
期刊:Cerebrovascular Diseases
[S. Karger AG]
日期:2009-01-01
卷期号:28 (5): 514-521
被引量:39
摘要
Previous clinical studies have shown that Neuroaid (MLC 601) may be beneficial in post-stroke rehabilitation. Our aim was to investigate the efficacy of Neuroaid on motor recovery in ischemic stroke patients using rehabilitation endpoints in accordance with the International Conference on Harmonization/Good Clinical Practice guidelines, in order to provide predictive information for further larger trials.This is a phase II double-blind, placebo-controlled pilot study of 40 subjects admitted with a recent (less than 1 month) ischemic stroke. All subjects were given either Neuroaid or placebo, 4 capsules 3 times a day for 4 weeks. Fugl-Meyer Assessment (FMA), National Institutes of Health Stroke Scale and Functional Independence Measure scores were measured at initiation of the treatment, and at 4 and 8 weeks.None of the outcomes was statistically significant between the two groups. However, FMA scores showed a positive trend for improvement with Neuroaid treatment over time. Subgroup analysis of subjects with posterior circulation infarction and severe stroke both showed a tendency for better recovery.Some positive trends were observed in the Neuroaid group. A larger multicenter trial focusing on severe stroke patients is needed to better evaluate the role of Neuroaid in aiding stroke recovery in rehabilitation.
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