Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance

Background To analyze the association between the plasma C1q/TNF-related protein-3 (CTRP-3) concentrations, obesity, and type II diabetes in the Chinese population. Methods The plasma CTRP-3 concentrations were analyzed in 174 Chinese subjects with obesity (n = 43), type II diabetes (n = 41), obesity combined with type II diabetes (n = 45), and healthy subjects (n = 45), as were various clinical parameters of obesity-related metabolic disorders and adipokines. Results The plasma CTRP-3 concentrations were significantly lower in patients with obesity and type II diabetes than in healthy subjects ( P P P  = .023), triglyceride (β = −0.147, P  = .040), and homeostasis model assessment for insulin resistance (β = −0.172, P  = .031) were independently correlated with circulating CTRP-3. Multivariate logistic regression analysis revealed that plasma CTRP-3 concentrations were significantly correlated with obesity, even after adjusting for glucose metabolic factors. Conclusions Chinese patients with obesity and type II diabetes have significantly lower plasma CTRP-3 concentrations than healthy subjects do, and plasma CTRP-3 is strongly associated with glucose and lipid metabolism, chronic inflammation, and insulin resistance.