Phenotypic models of T cell activation

T细胞受体 计算生物学 主要组织相容性复合体 计算机科学 等级制度 T细胞 表型 生物 免疫系统 遗传学 市场经济 基因 经济
作者
Melissa Lever,Philip K. Maini,P. Anton van der Merwe,Omer Dushek
出处
期刊:Nature Reviews Immunology [Nature Portfolio]
卷期号:14 (9): 619-629 被引量:147
标识
DOI:10.1038/nri3728
摘要

There is currently no single model that fits the wealth of experimental data that relate T cell activation to T cell receptor–peptide–MHC binding parameters. Here, the authors analyse and reformulate the published models, and suggest that a kinetic proofreading model that involves limited T cell receptor signalling provides the best fit. T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on the binding parameters that govern the interactions between T cell receptors (TCRs) and peptide–MHC complexes (pMHC complexes). Despite extensive experimental studies, the relationship between the TCR–pMHC binding parameters and T cell activation remains controversial. To make sense of conflicting experimental data, a variety of verbal and mathematical models have been proposed. However, it is currently unclear which model or models are consistent or inconsistent with experimental data. A key problem is that a direct comparison between the models has not been carried out, in part because they have been formulated in different frameworks. For this Analysis article, we reformulated published models of T cell activation into phenotypic models, which allowed us to directly compare them. We find that a kinetic proofreading model that is modified to include limited signalling is consistent with the majority of published data. This model makes the intriguing prediction that the stimulation hierarchy of two different pMHC complexes (or two different TCRs that are specific for the same pMHC complex) may reverse at different pMHC concentrations.
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