医学
麻疹
接种疫苗
儿科
麻疹病毒
呼吸道感染
呼吸道
呼吸系统
免疫学
内科学
作者
Lone Graff Stensballe,Ernesto Nante,Inge Panum Jensen,Poul‐Erik Kofoed,Anja Poulsen,Henrik Jensen,Melanie J. Newport,Arnaud Marchant,Peter Aaby
出处
期刊:Vaccine
[Elsevier BV]
日期:2004-10-07
卷期号:23 (10): 1251-1257
被引量:230
标识
DOI:10.1016/j.vaccine.2004.09.006
摘要
Among measles unvaccinated infants in Guinea-Bissau, we tested whether case infants with acute lower respiratory tract infection (ALRI), especially ALRI caused by respiratory syncytial virus (RSV), were more likely to be Bacille Calmette Guérin (BCG)-unvaccinated and to have no scar after BCG vaccination than were control infants without symptoms of ALRI. Three hundred and eighty-six case infants with ALRI were identified at a paediatric clinic (N = 84), a health centre (N = 82), and in a community morbidity surveillance system (N = 220). Control infants were matched on sex, age, and district and were also measles unvaccinated. In ALRI case infants, the adjusted OR of being BCG unvaccinated was 2.87 (1.31–6.32), 1.72 (0.48–6.19) in boys and 4.45 (1.48–13.4) in girls. Among BCG vaccinated ALRI case infants, the adjusted OR of having no BCG scar was 1.54 (0.86–2.75), 0.93 (0.45–1.91) in boys and 2.70 (1.21–6.02) in girls. In ALRI case infants with RSV infection, similar trends were observed. BCG vaccination may have a non-targeted protective effect against ALRI, the effect being most marked in girls.
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