Heme Oxygenase Activity: Current Methods and Applications

血红素加氧酶 血红素 一氧化碳 化学 血红素蛋白 生物化学 催化作用
作者
Stefan W. Ryter,Egil Kvam,Rex M. Tyrrell
出处
期刊:Humana Press eBooks [Humana Press]
卷期号:: 369-391 被引量:38
标识
DOI:10.1385/1-59259-054-3:369
摘要

AbstractThe heme oxygenase enzymes (HO-1 and HO-2) oxidize heme to biliver-din-IXα (BVIXα), releasing carbon monoxide (CO) and iron (Fig. 1). HO enzymes control the rate of heme degradation and, consequently, also control the redistribution of the heme iron (1). The CO generated from the HO reaction affects signal transduction pathways in neuronal and vascular systems (2). The pathway of heme metabolism. Heme oxygenase (HO-1), first described as a microsomal mixed-function oxygenase (E.C. 1:14:99:3, heme-hydrogen donor:oxygen oxidoreductase), catalyzes the rate-determining step in heme metabolism. Both heme oxygenase isozymes (HO-1 and HO-2) oxidize heme (ferriprotoporphyrin IX) to the bile pigment biliverdin-IXa, in a reaction requiring 3 mol of molecular oxygen. The accessory enzyme, NADPH:cytochrome p-450 reductase, reduces the ferric heme iron as a prerequisite for each cycle of oxygen binding and (continued) oxygen activation. The cleavage of the heme ring frees the coordinated iron, as well as the α-methene bridge carbon as carbon monoxide. The principle HO reaction product, biliverdin-IXα, is further metabolized by divalent reduction to form bilirubin-IXα, by NAD(P)H:biliverdin reductase. Heme side chains are designated as M, methyl; V, vinyl; and P, propionate. KeywordsCrude ExtractHeme OxygenaseHeme IronBile PigmentCirculate Water BathThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
一路硕博应助完美的海秋采纳,获得10
刚刚
嘿嘿发布了新的文献求助10
刚刚
1秒前
一一应助13654135090采纳,获得30
1秒前
华仔应助独特笙采纳,获得10
2秒前
大力的小熊猫完成签到 ,获得积分10
2秒前
2秒前
3秒前
yihe发布了新的文献求助10
4秒前
爱笑秋白完成签到,获得积分10
4秒前
5秒前
FashionBoy应助doc.level采纳,获得10
6秒前
小蘑菇应助负责的孤菱采纳,获得10
6秒前
万能图书馆应助三三采纳,获得10
7秒前
8秒前
9秒前
传奇3应助liherong采纳,获得10
9秒前
9秒前
11秒前
Gilana应助嘿嘿采纳,获得10
11秒前
落日余晖完成签到,获得积分10
11秒前
笨笨西装发布了新的文献求助10
12秒前
12秒前
12秒前
wlw发布了新的文献求助10
13秒前
科研通AI2S应助Roman采纳,获得10
14秒前
qiang完成签到,获得积分10
15秒前
15秒前
星辰大海应助泰乐采纳,获得10
16秒前
Billy应助nanwan采纳,获得30
16秒前
QiWei完成签到 ,获得积分10
16秒前
16秒前
16秒前
lll发布了新的文献求助10
17秒前
17秒前
深情安青应助天子采纳,获得10
17秒前
xiaxue完成签到,获得积分20
17秒前
真洋子哈完成签到,获得积分10
18秒前
认真的一刀完成签到,获得积分10
18秒前
yihe完成签到,获得积分10
18秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Sensory analysis — Methodology — Guidelines for the measurement of the performance of a quantitative descriptive sensory panel 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3245962
求助须知:如何正确求助?哪些是违规求助? 2889582
关于积分的说明 8259253
捐赠科研通 2558026
什么是DOI,文献DOI怎么找? 1386905
科研通“疑难数据库(出版商)”最低求助积分说明 650340
邀请新用户注册赠送积分活动 626748