Crystal engineering of C60 fullerenes trapped in covalent organic frameworks for enhanced electrochemical impedimetric aptasensing performance

It is very important to trap fullerenes (C60) in covalent organic frameworks (COFs) to obtain functional composites (C60@COF) because of their remarkable physicochemical properties. A mesoporous COF was used as an available scaffold for in situ encapsulating electroactive C60. The C60@COF composite possesses many advantages, such as high surface area, fine stability, good electroactive and large conjugated structure, resulting in the C60@COF-modified electrode with high load capacity of aptamer stands. The electrochemical impedimetric aptasensor can determinate tobramycin with an extremely low limit of detection (1.38 fg·mL−1). Also, the impedimetric aptasensor has high specificity, nice stability, available repeatability and good regeneration.