低聚果糖
化学
链脲佐菌素
丙二醛
甘油三酯
内分泌学
内科学
一氧化氮
糖尿病
胆固醇
高密度脂蛋白
超氧化物歧化酶
生物化学
抗氧化剂
医学
有机化学
作者
Ping Yuan,Taili Shao,Jun Hyun Han,Chunyan Liu,Guodong Wang,HE Shu-guang,Shiqi Xu,Sihui Nian,Kaoshan Chen
标识
DOI:10.1016/j.jff.2021.104703
摘要
Burdock roots are rich in inulin-type burdock fructooligosaccharide (BFO). However, the antidiabetic effect of BFO remains unknown. In this study, BFO was purified using DEAE-52 and G-75. The purity of BFO was 99.4%, the peak-average molecular weight (Mp) was 2958 Da. BFO inhibited α-glucosidase activity with an IC50 of 0.4996 mg/mL. Streptozotocin (STZ) and high-fat diet (HFD) induced diabetic mice were used to test the anti diabetic effect of BFO. BFO reduced fasting blood glucose (FBG) levels, relieved rapid weight loss, and improved glucose tolerance after six weeks of treatment. In addition, BFO reduced serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), reactive oxygen species (ROS), malondialdehyde (MDA), and nitric oxide synthetase (NOS) levels, while increasing superoxide dismutase (SOD) and high-density lipoprotein cholesterol (HDL-C) levels. BFO also reduced islet, liver, and kidney damage. Based on these findings, BFO possesses potent antidiabetic effects on diabetic mice.
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