医学
临床终点
糖尿病
内科学
相对风险
截肢
不利影响
荟萃分析
置信区间
严重肢体缺血
风险因素
外科
血管疾病
动脉疾病
临床试验
内分泌学
作者
Jingyang Luan,Jie Xu,Weiquan Zhong,Yan Zhou,Hao Líu,Kai Qian
出处
期刊:Angiology
[SAGE]
日期:2021-09-21
卷期号:73 (4): 318-330
被引量:9
标识
DOI:10.1177/00033197211042494
摘要
Many studies have investigated the influence of diabetes mellitus (DM) on outcomes in patients with peripheral artery disease (PAD). We performed a meta-analysis of the outcomes of PAD treatments in DM patients compared with those without DM. Long-term mortality was the primary endpoint. Secondary endpoints were in-hospital/30-day mortality, primary/secondary patency, amputation, and limb salvage. Thirty-one studies reporting 58113 patients were eligible for enrollment. The mean follow-up duration ranged from 1 to 89 months. DM was significantly associated with long-term mortality (relative risk (RR) = 1.67; 95% confidence intervals (CI), 1.43-1.94; P < .001). DM was also associated with significantly lower primary patency (RR = 0.74; 95% CI, 0.58-0.95; P = .001) and secondary patency (RR = 0.80; 95% CI, 0.67-0.96; P = .009). DM is associated with worse outcomes and adverse prognosis of treatment in patients with PAD, and may therefore be a modifiable risk factor for poor prognosis in PAD patients.
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