Exenatide Adjunct to Nicotine Patch Facilitates Smoking Cessation and May Reduce Post-Cessation Weight Gain: A Pilot Randomized Controlled Trial

戒烟 辅助 随机对照试验 医学 尼古丁贴片 尼古丁替代疗法 体重增加 尼古丁 物理疗法 精神科 内科学 体重 替代医学 安慰剂 病理 哲学 语言学
作者
Luba Yammine,Charles E. Green,Thomas R. Kosten,Constanza de Dios,Robert Suchting,Scott D. Lane,Christopher D. Verrico,Joy M. Schmitz
出处
期刊:Nicotine & Tobacco Research [Oxford University Press]
卷期号:23 (10): 1682-1690 被引量:21
标识
DOI:10.1093/ntr/ntab066
摘要

Abstract Introduction Approved pharmacological treatments for smoking cessation are modestly effective, underscoring the need for improved pharmacotherapies. Glucagon-like peptide-1 receptor (GLP-1R) agonists attenuate the rewarding effects of nicotine in preclinical studies. We examined the efficacy of extended-release exenatide, a GLP-1R agonist, combined with nicotine replacement therapy (NRT, patch) for smoking cessation, craving, and withdrawal symptoms, with post-cessation body weight as a secondary outcome. Methods Eighty-four prediabetic and/or overweight smokers were randomized (1 : 1) to once-weekly placebo or exenatide, 2 mg, subcutaneously. All participants received NRT (21 mg) and brief smoking cessation counseling. Seven-day point prevalence abstinence (expired CO level ≤5 ppm), craving, withdrawal, and post-cessation body weight were assessed following 6 weeks of treatment. A Bayesian approach for analyzing generalized linear models yielded posterior probabilities (PP) to quantify the evidence favoring hypothesized effects of treatment on the study outcomes. Results Exenatide increased the risk for smoking abstinence compared to placebo (46.3% and 26.8%, respectively), (risk ratio [RR] = 1.70; 95% credible interval = [0.96, 3.27]; PP = 96.5%). Exenatide reduced end-of-treatment craving in the overall sample and withdrawal among abstainers. Post-cessation body weight was 5.6 pounds lower in the exenatide group compared to placebo (PP = 97.4%). Adverse events were reported in 9.5% and 2.3% of participants in the exenatide and placebo groups, respectively. Conclusions Exenatide, in combination with the NRT improved smoking abstinence, reduced craving and withdrawal symptoms, and decreased weight gain among abstainers. Findings suggest that the GLP-1R agonist strategy is worthy of further research in larger, longer duration studies. Implications Despite considerable progress in tobacco control, cigarette smoking remains the leading cause of preventable disease, disability, and death. In this pilot study, we showed that extended-release exenatide, a glucagon-like peptide-1 receptor agonist, added to the nicotine patch, improved abstinence and mitigated post-cessation body weight gain compared to patch alone. Further research is needed to confirm these initial positive results.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
沈静完成签到,获得积分10
3秒前
5秒前
loski发布了新的文献求助10
5秒前
marina完成签到 ,获得积分20
6秒前
9秒前
时尚俊驰发布了新的文献求助10
9秒前
10秒前
文献发布了新的文献求助30
11秒前
14秒前
我嘞个豆完成签到,获得积分10
14秒前
爱笑晓曼发布了新的文献求助10
15秒前
wdy111应助sc采纳,获得20
15秒前
敏感初露发布了新的文献求助10
15秒前
隐形曼青应助机智思真采纳,获得10
18秒前
思源应助时尚俊驰采纳,获得10
18秒前
可爱的函函应助敏感初露采纳,获得10
18秒前
19秒前
爆米花应助橙子采纳,获得10
22秒前
量子星尘发布了新的文献求助10
24秒前
阿满完成签到 ,获得积分10
25秒前
王馨雨完成签到,获得积分10
26秒前
在水一方应助袁涛采纳,获得10
26秒前
爱笑晓曼完成签到,获得积分10
29秒前
30秒前
31秒前
nuoran发布了新的文献求助10
32秒前
32秒前
乐乐宝完成签到,获得积分10
33秒前
34秒前
彭于晏应助阿钉采纳,获得10
35秒前
孙燕应助阿钉采纳,获得10
35秒前
整齐小松鼠应助阿钉采纳,获得10
35秒前
jszhoucl发布了新的文献求助10
36秒前
一定行发布了新的文献求助10
36秒前
jxlu发布了新的文献求助10
37秒前
39秒前
橙子发布了新的文献求助10
39秒前
科研通AI5应助科研通管家采纳,获得10
40秒前
李健应助科研通管家采纳,获得10
40秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989378
求助须知:如何正确求助?哪些是违规求助? 3531442
关于积分的说明 11254002
捐赠科研通 3270126
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173