微尺度化学
细胞外小泡
小泡
微流控
胞外囊泡
分泌物
细胞外
微泡
细胞生物学
单细胞分析
细胞内
细胞
纳米技术
化学
生物物理学
膜
生物
材料科学
生物化学
数学
小RNA
数学教育
基因
作者
Fengjiao Zhu,Yahui Ji,Jiu Deng,Linmei Li,Xue Bai,Xianming Liu,Bingcheng Lin,Yao Lu
标识
DOI:10.1016/j.cclet.2021.09.058
摘要
Extracellular vesicles (EVs) are membrane vesicles secreted by cells, playing critical roles in mediating intercellular communications for various physiological and pathological processes. Most of the EV analysis is currently performed at the bulk level, obscuring the origin of the EVs and diverse characteristics of the individual extracellular vesicle. Technologies to analyze the extracellular vesicles at the single-cell and single-vesicle levels are needed to evaluate EV comprehensively and decode the heterogeneity underlying EV secretion. Microfluidic platforms that could control and manipulate fluids at the microscale provide an efficient way to achieve the aims. Various microfluidics-based technologies are emerging to realize single-cell EV secretion analysis and single EV analysis, which would be summarized in this mini-review.
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