糖类聚合物
凝集素
聚糖
糖生物学
糖蛋白
粘蛋白
糖萼
生物
细胞生物学
唾液酸
细胞粘附
生物化学
化学
受体
生物物理学
细胞
有机化学
聚合物
共聚物
作者
Daniel J. Honigfort,Meghan O. Altman,Pascal Gagneux,Kamil Godula
标识
DOI:10.1073/pnas.2107896118
摘要
Significance Like other animal hosts, humans are constantly challenged by pathogens. This has led to an evolution of physical barriers coating all mucosal tissues, which are most vulnerable to infection. An important part of this defense is a dense brush of large proteins, called mucins, which are heavily decorated with sugars and keep pathogens at bay. Deciphering how pathogens overcome the mucin barrier is necessary to understand early stages of infection and to develop more effective treatments. By artificially installing a mucin-like shield on the surfaces of cells using synthetic sugar–bearing polymers, we have discovered a physical mechanism by which proteins and viruses can exploit this barrier to adhere to their targets more strongly.
科研通智能强力驱动
Strongly Powered by AbleSci AI