CD8型
免疫疗法
T细胞
免疫系统
转录因子
癌症研究
生物
细胞毒性T细胞
癌症免疫疗法
免疫学
细胞生物学
基因
遗传学
体外
作者
Jiaxue Zhang,Tong Lyu,Yaming Cao,Hui Feng
标识
DOI:10.1096/fj.202002566r
摘要
T cell factor-1 (TCF-1) (encoded by the TCF7 gene) is a transcription factor that plays important role during the T cell development and differentiation for T cell to exercise its functions including producing memory T cells. Not only TCF-1 can modulate the T cell development but also exerts various effects on the differentiation and function of mature CD8+ T cells. In addition, it drives the production and maintenance of the immune response of CD8+ T cells after PD-1 checkpoint blockade therapy. TCF-1 can serve as a potential target of immunotherapy and may provide promising novel treatment strategies for patients with cancer and infections. Moreover, TCF-1 is a potential biomarker of CD8+ T cell functionality to predict the efficacy of immunotherapy in fighting against cancer and infections. Herein, we summarize the role of TCF-1 in T cell development and its applications in the treatment of cancer and infectious diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI