神经保护
氧化应激
血脑屏障
活性氧
光热治疗
材料科学
普鲁士蓝
药物输送
药理学
生物物理学
化学
生物化学
医学
纳米技术
生物
中枢神经系统
内科学
电极
物理化学
电化学
作者
Yao Liu,Honghai Hong,Jincheng Xue,Jingshan Luo,Qiao Liu,Xiaojia Chen,Yue Pan,Jingwei Zhou,Zeming Liu,Tongkai Chen
标识
DOI:10.1021/acsami.1c12675
摘要
Mitochondrial dysfunction, which is directly involved in Parkinson's disease (PD), is characterized by the production of reactive oxygen species (ROS) and aberrant energy metabolism. Thus, regulating mitochondrial function might be an effective strategy to treat PD. However, the blood-brain barrier (BBB) presents a significant challenge for the intracerebral delivery of drugs. Here, we synthesized a zeolitic imidazolate framework 8-coated Prussian blue nanocomposite (ZIF-8@PB), which was encapsulated with quercetin (QCT), a natural antioxidant, to treat PD. ZIF-8@PB-QCT exhibited superior near-infrared radiation (NIR) response and penetrated through the BBB to the site of mitochondrial damage guided by the photothermal effect. In the mice model of PD, the QCT released from ZIF-8@PB-QCT significantly increased the adenosine triphosphate levels, reduced the oxidative stress levels, and reversed dopaminergic neuronal damage as well as PD-related behavioral deficits without any damage to the normal tissues. Furthermore, we explored the underlying neuroprotective mechanism of ZIF-8@PB-QCT that was mediated by activating the PI3K/Akt signaling pathway. Thus, combined with noninvasive NIR radiation, the biocompatible ZIF-8@PB-QCT nanocomposite could be used to treat neurodegenerative diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI