tert‐Butyl Hydroperoxide‐Initiated Radical Cyclization of 1‐(Allyloxy)‐2‐(1‐Arylvinyl)Benzenes with Sulfinic Acids to Access Sulfonated Benzoxepines

Abstract A tert ‐butyl hydroperoxide‐initiated radical cyclization of 1‐(allyloxy)‐2‐(1‐arylvinyl)benzenes with sulfinic acids for the construction of sulfonated benzoxepines is developed. This reaction involves a radical pathway and offers a straightforward route to the formation of seven‐membered ring via sulfonylation/cyclization process. This methodology features mild reaction conditions, a broad substrate scope and good functional group tolerance. magnified image