CD8型
转移
细胞毒性T细胞
原发性肿瘤
转移性肿瘤
生物
癌症研究
免疫学
免疫系统
癌症
体外
遗传学
生物化学
作者
Paulino Tallón de Lara,Héctor Castañón,Michelle Sterpi,Maries van den Broek
标识
DOI:10.1016/j.trecan.2021.10.006
摘要
Metastasis is an intricate process whereby tumor cells migrate from the primary tumor, survive in the circulation, seed distal organs, and proliferate to create metastatic foci. CD8+ T cells can detect and eliminate tumor cells. Research on CD8+ T cell-dependent antitumor immunity has classically focused on its role in the primary tumor. There is increasing evidence, however, that CD8+ T cells have unique antimetastatic functions in various steps of the metastatic cascade. Here, we review the mechanisms whereby CD8+ T cells control metastatic lesions. We discuss their role in each step of metastasis, metastatic dormancy, and metastatic clonal evolution as well as the consequent clinical repercussions.
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