免疫学
自身免疫
生物
免疫系统
银屑病
周边公差
自身免疫性肝炎
肝炎
作者
Haijing Wu,Wei Liao,Qianwen Li,Hai Long,Heng Yin,Ming Zhao,Vera Sau‐Fong Chan,Chak Sing Lau,Qianjin Lu
标识
DOI:10.1016/j.autrev.2018.03.014
摘要
The tissue-resident memory T (TRM) cells constitute a newly identified subset of memory T cells which are non-circulating and they persist for long-term in epithelial barrier tissues, including skin, lung, gastrointestinal tract and reproductive tract, and in non-barrier tissues, including brain, kidney, pancreas and joint. These cells provide rapid on-site immune protection against previous exposed pathogens in peripheral tissues. There cells are transcriptionally, functionally and phenotypically distinguished from circulating effector memory T cells. In addition to their protective functions, increasing evidence reveals that autoreactive and/or aberrantly activated TRM cells may be involved in the pathogenesis of autoimmune disorders such as psoriasis and, as recently reported, may contribute to vitiligo, autoimmune hepatitis and rheumatoid arthritis. Therefore, this review aims to summarize the current progress in the biology of TRM cells, such as the newly identified TRM markers, upstream regulators, and the functions of TRM cells. We also discuss the contributions of TRM cells to the development of autoimmunity to broaden our understanding of autoimmune diseases and to provide novel potential therapeutic strategies for these diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI