Short-term exposure to ambient fine particulate matter and out-of-hospital cardiac arrest: a nationwide case-crossover study in Japan

医学 交叉研究 污染物 二氧化氮 环境卫生 人口 条件logistic回归 入射(几何) 空气污染物 空气污染 环境科学 急诊医学 毒理 气象学 化学 病理 有机化学 替代医学 物理 光学 生物 安慰剂
作者
Bing Zhao,Fay H. Johnston,Farhad Salimi,Masahiko Kurabayashi,Kazuaki Negishi
出处
期刊:The Lancet Planetary Health [Elsevier]
卷期号:4 (1): e15-e23 被引量:63
标识
DOI:10.1016/s2542-5196(19)30262-1
摘要

PM2·5 is an important but modifiable environmental risk factor, not only for pulmonary diseases and cancers, but for cardiovascular health. However, the evidence regarding the association between air pollution and acute cardiac events, such as out-of-hospital cardiac arrest (OHCA), is inconsistent, especially at concentrations lower than the WHO daily guideline (25 μg/m3). This study aimed to determine the associations between exposure to ambient air pollution and the incidence of OHCA.In this nationwide case-crossover study, we linked prospectively collected population-based registry data for OHCA in Japan from Jan 1, 2014, to Dec 31, 2015, with daily PM2·5, carbon monoxide (CO), nitrogen dioxide (NO2), photochemical oxidants (Ox), and sulphur dioxide (SO2) exposure on the day of the arrest (lag 0) or 1-3 days before the arrest (lags 1-3), as well as the moving average across days 0-1 and days 0-3. Daily exposure was calculated by averaging the measurements from all PM2·5 monitoring stations in the same prefecture. The effect of PM2·5 on risk of all-cause or cardiac OHCA was estimated using a time-stratified case-crossover design coupled with conditional logistic regression analysis, adjusted for daily temperature and relative humidity. Single-pollutant models were also investigated for the individual gaseous pollutants (CO, NO2, Ox, and SO2), as well as two-pollutant models for PM2·5 with these gaseous pollutants. Subgroup analyses were done by sex and age.Over the 2 years, 249 372 OHCAs were identified, with 149 838 (60·1%) presumed of cardiac origin. The median daily PM2·5 was 11·98 μg/m3 (IQR 8·13-17·44). Each 10 μg/m3 increase in PM2·5 was associated with increased risk of all-cause OHCA on the same day (odds ratio [OR] 1·016, 95% CI 1·009-1·023) and at lags of up to 3 days, ranging from OR 1·015 (1·008-1·022) at lag 1 to 1·033 (1·023-1·043) at lag 0-3. Results for cardiac OHCA were similar (ORs ranging from 1·016 [1·007-1·025] at lags 1 and 2 to 1·034 [1·021-1·047] at lag 0-3). Patients older than 65 years were more susceptible to PM2·5 exposure than younger age groups but no sex differences were identified. CO, Ox, and SO2 were also positively associated with OHCA while NO2 was not. However, in two-pollutant models of PM2·5 and gaseous pollutants, only PM2·5 (positive association) and NO2 (negative association) were independently associated with increased risk of OHCA.Short-term exposure to PM2·5 was associated with an increased risk of OHCA even at relatively low concentrations. Regulatory standards and targets need to incorporate the potential health gains from continual air quality improvement even in locations already meeting WHO standards.None.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Akim应助小写采纳,获得10
刚刚
1秒前
科研通AI2S应助11111采纳,获得10
1秒前
2秒前
感动的老四完成签到,获得积分10
3秒前
4秒前
勤奋的幻莲完成签到,获得积分10
5秒前
闪耀吨吨完成签到,获得积分10
5秒前
5秒前
6秒前
朱梅琳完成签到,获得积分20
6秒前
尊敬鸵鸟完成签到,获得积分10
10秒前
doni发布了新的文献求助10
10秒前
11秒前
帅气的海露完成签到 ,获得积分10
11秒前
11秒前
12秒前
13秒前
222123完成签到,获得积分10
13秒前
14秒前
14秒前
小写发布了新的文献求助10
15秒前
CodeCraft应助jessie采纳,获得10
16秒前
16秒前
林翔翔发布了新的文献求助10
18秒前
tian发布了新的文献求助10
18秒前
18秒前
Jessica发布了新的文献求助10
19秒前
19秒前
怕黑行恶完成签到,获得积分10
19秒前
Ann发布了新的文献求助10
20秒前
谨慎不二发布了新的文献求助50
21秒前
搜集达人应助幸福海豚采纳,获得10
21秒前
Yara.H发布了新的文献求助10
21秒前
Jasper应助meimei采纳,获得10
22秒前
22秒前
23秒前
23秒前
23秒前
23秒前
高分求助中
Sustainability in Tides Chemistry 2000
The ACS Guide to Scholarly Communication 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3076615
求助须知:如何正确求助?哪些是违规求助? 2729583
关于积分的说明 7509104
捐赠科研通 2377778
什么是DOI,文献DOI怎么找? 1260780
科研通“疑难数据库(出版商)”最低求助积分说明 611183
版权声明 597203