已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Subclinical left atrial dysfunction profiles for prediction of cardiac outcome in the general population

医学 心脏病学 心房颤动 内科学 亚临床感染 危险系数 人口 射血分数 心力衰竭 置信区间 环境卫生
作者
Nicholas Cauwenberghs,François Haddad,František Sabovčik,Yukari Kobayashi,Myriam Amsallem,Daniel A. Morris,Jens‐Uwe Voigt,Tatiana Kuznetsova
出处
期刊:Journal of Hypertension [Ovid Technologies (Wolters Kluwer)]
卷期号:38 (12): 2465-2474 被引量:26
标识
DOI:10.1097/hjh.0000000000002572
摘要

Objective: Echocardiographic definitions of subclinical left atrial dysfunction based on epidemiological data remain scarce. In this population study, we derived outcome-driven thresholds for echocardiographic left atrial function parameters discriminating between normal and abnormal values. Methods: In 1306 individuals (mean age, 50.7 years; 51.6% women), we echocardiographically assessed left atrial function and LV global longitudinal strain. We derived cut-off values for left atrial emptying fraction (LAEF), left atrial function index (LAFI) and left atrial reservoir strain (LARS) to define left atrial dysfunction using receiver-operating curve threshold analysis. Main outcome was the incidence of cardiac events and atrial fibrillation (AFib) on average 8.5 years later. Results: For prediction of new-onset AFib, left atrial cut-offs yielding the best balance between sensitivity and specificity (highest Youden index) were: LAEF less than 55%, LAFI less than 40.5 and LARS less than 23%. Applying these cut-offs, abnormal LAEF, LAFI and LARS were, respectively, present in 27, 37.1 and 18.1% of the cohort. Abnormal LARS (<23%) was independently associated with higher risk for cardiac events and new-onset AFib (P ≤ 0.012). Participants with both abnormal LAEF and LARS presented a significantly higher risk to develop cardiac events (hazard ratio: 2.10; P = 0.014) and AFib (hazard ratio: 6.45; P = 0.0036) than normal counterparts. The concomitant presence of an impaired LARS and LV global longitudinal strain improved prognostic accuracy beyond a clinical risk model for cardiac events and the CHARGE-AF Risk Score for AFib. Conclusion: Left atrial dysfunction based on outcome-driven thresholds predicted cardiac events and AFib independent of conventional risk factors. Screening for subclinical left atrial and LV systolic dysfunction may enhance cardiac disease prediction in the community.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
红红发布了新的文献求助10
刚刚
发文时长两年半完成签到,获得积分10
6秒前
未央天完成签到 ,获得积分10
7秒前
11秒前
12秒前
12秒前
xjcy应助俏皮的凝珍采纳,获得10
12秒前
复杂的书南完成签到,获得积分10
14秒前
优美傲安发布了新的文献求助30
15秒前
liweiDr发布了新的文献求助10
16秒前
18秒前
搜集达人应助科研通管家采纳,获得10
18秒前
orixero应助科研通管家采纳,获得10
18秒前
隐形曼青应助科研通管家采纳,获得10
18秒前
加菲丰丰应助科研通管家采纳,获得20
18秒前
Hello应助科研通管家采纳,获得10
18秒前
18秒前
18秒前
Skywalker完成签到,获得积分10
18秒前
19秒前
20秒前
23秒前
JianminLuo发布了新的文献求助10
24秒前
treeman完成签到,获得积分10
24秒前
01发布了新的文献求助10
25秒前
斯文败类应助俏皮的凝珍采纳,获得10
26秒前
27秒前
皮蛋完成签到,获得积分10
28秒前
29秒前
科研通AI2S应助虚拟的振家采纳,获得10
29秒前
领导范儿应助屈狒狒采纳,获得10
31秒前
31秒前
31秒前
31秒前
Yiyi发布了新的文献求助10
32秒前
up发布了新的文献求助10
32秒前
椿·完成签到 ,获得积分10
33秒前
35秒前
冷酷愚志完成签到,获得积分10
36秒前
zhangyafei发布了新的文献求助10
36秒前
高分求助中
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Handbook of Qualitative Cross-Cultural Research Methods 600
Chen Hansheng: China’s Last Romantic Revolutionary 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3139294
求助须知:如何正确求助?哪些是违规求助? 2790209
关于积分的说明 7794379
捐赠科研通 2446597
什么是DOI,文献DOI怎么找? 1301309
科研通“疑难数据库(出版商)”最低求助积分说明 626124
版权声明 601109