[The correlation between functional magnetic resonance imaging features and expression of Her-2 in breast cancer].

Objective: To explore the correlation between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), magnetic resonance diffusion-weighted imaging (DWI) images of breast cancer and human epidermal growth factor receptor-2 (Her-2) expression. Methods: A retrospective analysis of 84 patients with breast cancer confirmed by biopsy from January 2012 to December 2016 in Zhejiang University Lishui Hospital was conducted. The data of DCE-MRI, DWI scanning were collected before surgery and Her-2 was detected by immunohistochemistry (IHC). Then, all the patients were divided into Her-2 positive group and Her-2 negative group according to Her-2 expression. There were 44 cases in the Her-2 positive group and 40 cases in the Her-2 negative group. The differences in the characteristics of the lesion morphology, time-signal intensity curve (TIC), early enhancement rate and apparent diffusion coefficient (ADC) were compared, and their correlation with Her-2 expression was analyzed. Results: Of the 84 lesions, 12 were orthotopic ductal carcinoma, 6 were lobular carcinoma, and 66 were invasive ductal carcinoma. There were significant differences in lesion morphology (P=0.012) and TIC curve morphology (P=0.038) between Her-2 positive group and negative group. At the same time, the early enhancement rate (P=0.012) and ADC value (P=0.038) of Her-2 positive group were significantly higher than those of negative group. Except morphology of segmental lesions and TIC curve morphology, other characteristic parameters were correlated to Her-2 (all P<0.05). The correlation coefficients between early enhancement rate, ADC value and Her-2 expression were as high as 0.758 and 0.809 (all P<0.05). Conclusions: The morphology of breast cancer lesions, time-signal intensity curve, early enhancement rate and ADC value are all correlated with Her-2 expression.The early enhancement rate and ADC value are significantly positively correlated with Her-2 expression.目的： 探讨乳腺癌的动态增强磁共振成像（DCE-MRI）和磁共振扩散加权成像（DWI）与人表皮生长因子受体2（Her-2）表达的相关性。 方法： 回顾分析浙江大学丽水医院2012年1月至2016年12月经手术病理证实的84例乳腺癌患者，年龄36~73岁，均在术前行DCE-MRI及DWI扫描检查，并采用免疫组化方法（IHC）检测Her-2表达情况，根据Her-2表达情况分为Her-2阳性组和Her-2阴性组，其中Her-2阳性组44例，年龄（48±10）岁；Her-2阴性组40例，年龄（49±8）岁，比较两组各特征参数的差异，并分析其与Her-2表达的相关性。 结果： 84个病灶中导管原位癌12个，小叶癌6个，浸润性导管癌66个，两组患者一般资料之间差异均无统计学意义。Her-2阳性组和阴性组的病灶形态（P=0.012）和时间-信号强度曲线（TIC）形态（P=0.038）差异均有统计学意义，同时Her-2阳性组的早期强化率（P=0.012）和表观扩散系数（ADC）值（P=0.038）均明显高于阴性组。通过相关性分析发现，除段样病灶形态和平台型TIC曲线形态与Her-2表达无相关性，其他特征参数均存在相关性（均P<0.05），其中早期强化率和ADC值均与Her-2表达的相关系数分别为0.758和0.809，且差异均有统计学意义（均P<0.05）。 结论： 乳腺癌病灶形态、TIC曲线形态、早期强化率和ADC值均与Her-2表达具有相关性，其中早期强化率和ADC值与Her-2表达强正相关。.