合成子
化学
奥西多尔
内酰胺
硫黄
产量(工程)
组合化学
立体化学
有机化学
催化作用
材料科学
冶金
作者
Hai‐Jun Leng,Qingzhu Li,Peng Xiang,Ting Qi,Qing‐Song Dai,Zhi-Qiang Jia,Chuan Gou,Xiang Zhang,Junlong Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-02-01
卷期号:23 (4): 1451-1456
被引量:21
标识
DOI:10.1021/acs.orglett.1c00130
摘要
Oxindoles and β-lactams are attractive structural motifs because of their unique biological importance. However, the fusion of the two moieties featuring 3,3′-spirocyclic scaffolds is a challenging task in organic synthesis. Herein we designed a novel type of oxindole-based azaoxyallyl cation synthons, which could readily participate in the [3 + 1] cyclization with sulfur ylides. With this protocol, a collection of 3,3-spiro[β-lactam]-oxindoles were facilely produced in up to 94% yield with perfect diastereoselectivity.
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