无精子症
内科学
医学
切断
精子发生
内分泌学
男科
睾酮(贴片)
精子
抗苗勒氏激素
横断面研究
精液
男性不育
参考范围
妇科
不育
激素
生物
怀孕
病理
物理
量子力学
遗传学
作者
Jian Wang,Na Lu,Shuolei Zhang,Zhangming Tang,Yifei Huang,Wei-Na Li,Gang Liu
摘要
Background The power of inhibin B to predict competent spermatogenesis is not fully understood. The aims of this study were to identify the reliable reference range of inhibin B among normozoospermic men in China and to evaluate the diagnostic accuracy of serum inhibin B level as a complementary predictor of successful sperm retrieval in patients with azoospermia. Methods This was a cross-sectional study. The male partners of 30 613 infertile couples who visited our hospital were investigated between March 2017 and March 2019. We analysed semen parameters, serum levels of reproductive hormones (inhibin B, FSH and testosterone) and sperm retrieval results from PESA/TESE in Chinese men. Results The normal reference range of inhibin B was 87.42-299.93 pg/mL among men with normozoospermia in China. Inhibin B levels were negatively correlated with age (r = -.111; P 77.72 pg/mL (sensitivity = 59.14%, specificity = 92.00% and AUC = 0.801). The inhibin B:FSH ratio (cutoff value > 6.98, sensitivity = 56.99%, specificity = 96.00% and AUC = 0.814) performed better than either the inhibin B level or the FSH level alone. Conclusion A new reference range for serum inhibin B was established in China. However, neither serum inhibin B, FSH nor their ratio is adequate for men to decide whether to undergo PESA/TESE to determine the adequacy of spermatogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI