化学
碘
硫化物
组合化学
催化作用
选择性
卤化
反应条件
有机化学
作者
Wenqi Zhao,Feng Zhang,Guo‐Jun Deng
标识
DOI:10.1021/acs.joc.0c02078
摘要
An iodine-promoted divergent thiolation of unprotected anilines with thiols for the synthesis of sulfide anilines has been described. The combinational use of I2 and DMSO played an important role to realize this kind of transformation without the aid of a metal catalyst and strong oxidants. The reaction selectivity was well controlled to provide mono-, bis-, and trisubstituted diaryl sulfide derivatives. More importantly, iodination and sulfenylation can occur simultaneously to provide useful multifunctionalized iodoaniline products. This method afforded an efficient protocol for the construct C–S and C–I bonds from the C–H bond under mild reaction conditions.
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