端粒酶
衰老
癌症
中医药
生物
癌细胞
癌症治疗
天然产物
癌症研究
细胞
程序性细胞死亡
细胞生长
癌细胞系
DNA损伤
生物信息学
医学
细胞生物学
DNA
细胞凋亡
遗传学
基因
生物化学
病理
替代医学
作者
Yiman Liu,Shenshen Yang,Kailong Wang,Jia Lu,Xiaomei Bao,Rui Wang,Yuling Qiu,Tao Wang,Haiyang Yu
摘要
Abstract Cancer is the principal cause of death and a dominant public health problem which seriously threatening human life. Among various ways to treat cancer, traditional Chinese medicine (TCM) and natural products have outstanding anti‐cancer effects with their unique advantages of high efficiency and minimal side effects. Cell senescence is a physiological process of cell growth stagnation triggered by stress, which is an important line of defence against tumour development. In recent years, active ingredients of TCM and natural products, as an interesting research hotspot, can induce cell senescence to suppress the occurrence and development of tumours, by inhibiting telomerase activity, triggering DNA damage, inducing SASP, and activating or inactivating oncogenes. In this paper, the recent research progress on the main compounds derived from TCM and natural products that play anti‐cancer roles by inducing cell senescence is systematically reviewed, aiming to provide a reference for the clinical treatment of pro‐senescent cancer.
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