The emerging data on choice of optimal therapy for locally advanced nasopharyngeal carcinoma.

作者
Edwin P. Hui,Brigette B.Y. Ma,Anthony T.C. Chan
出处
期刊:Current Opinion in Oncology [Lippincott Williams & Wilkins]
卷期号:32 (3): 187-195 被引量:5
标识
DOI:10.1097/cco.0000000000000622
摘要

Purpose of review We focus on the emerging data from randomized clinical trials for optimal integration of induction, concurrent, and/or adjuvant chemotherapy with intensity-modulated radiotherapy in locally advanced nasopharyngeal carcinoma (NPC), and the use of plasma Epstein-Barr virus (EBV) DNA for risk stratification. Recent findings Several phase 3 trials have shown that induction chemotherapy followed by concurrent chemoradiation (CRT) improved overall survival or disease-free survival when compared to CRT alone in stage III/IV NPC who is at high risk of distant metastases. The benefit of adjuvant chemotherapy following CRT when compared to CRT alone is uncertain. There are increasing clinical data supporting the use of plasma EBV DNA for risk stratification. There are growing clinical data supporting the integration of immune checkpoint inhibitors into the induction, concurrent, and/or adjuvant/maintenance phase of treatment in locally advanced NPC. Summary Concurrent chemoradiation remains the standard treatment backbone in locally advanced NPC. There is level 1 evidence for induction chemotherapy followed by CRT in stage III/IV NPC. There is increasing evidence against the indiscriminate use of adjuvant chemotherapy following CRT. With the increasing treatment intensification, future treatment algorithm in NPC should incorporate plasma EBV DNA and other biomarkers for risk stratification and treatment selection.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
12345完成签到,获得积分10
1秒前
丘比特应助Struggle采纳,获得10
1秒前
啦啦啦完成签到,获得积分20
1秒前
2秒前
AAA房地产小王关注了科研通微信公众号
2秒前
3秒前
多多发SCI完成签到,获得积分10
3秒前
zcious完成签到,获得积分10
3秒前
3秒前
cc发布了新的文献求助30
3秒前
Zed关闭了Zed文献求助
3秒前
4秒前
4秒前
fjc发布了新的文献求助10
4秒前
小青完成签到 ,获得积分10
4秒前
5秒前
一枚研究僧完成签到,获得积分0
5秒前
5秒前
guons完成签到 ,获得积分10
5秒前
yrq关注了科研通微信公众号
6秒前
to高坚果发布了新的文献求助10
6秒前
合适的毛豆完成签到,获得积分10
6秒前
顾矜应助Ing采纳,获得10
6秒前
torch132完成签到,获得积分10
6秒前
小二郎应助科研通管家采纳,获得10
6秒前
爆米花应助科研通管家采纳,获得10
6秒前
传奇3应助科研通管家采纳,获得10
6秒前
深情的友易完成签到 ,获得积分10
7秒前
脑洞疼应助科研通管家采纳,获得10
7秒前
科研通AI2S应助科研通管家采纳,获得30
7秒前
在水一方应助科研通管家采纳,获得10
7秒前
顾矜应助科研通管家采纳,获得10
7秒前
风趣初瑶应助科研通管家采纳,获得10
7秒前
领导范儿应助科研通管家采纳,获得10
7秒前
CipherSage应助科研通管家采纳,获得30
7秒前
7秒前
7秒前
7秒前
7秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968964
求助须知:如何正确求助?哪些是违规求助? 3513877
关于积分的说明 11170569
捐赠科研通 3249201
什么是DOI,文献DOI怎么找? 1794692
邀请新用户注册赠送积分活动 875297
科研通“疑难数据库(出版商)”最低求助积分说明 804755