化学
班级（哲学）
化学合成
立体化学
组合化学
体外
生物化学
人工智能
计算机科学
作者
Ralf Anderskewitz,Rolf Bauer,Gisela Bodenbach,Dirk Gester,Bernd Gramlich,Gerd Morschhäuser,F.W. Birke
标识
DOI：10.1016/j.bmcl.2004.11.039
摘要
A novel class of CCR3 modulators is described. Starting with lead compound 4a (Ki: 110 nM), which turned out to be an antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (Ki: 28 nM), which surprisingly proved to be an agonist.
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