广谱
恶二唑
化学
组合化学
药理学
生物活性
计算生物学
医学
生物
生物化学
有机化学
体外
作者
Ankur Vaidya,Shweta Jain,Priyanka Jain,Prachi Jain,Nidhi Tiwari,Rishabh Jain,Rashi Jain,Abhishek Kumar Jain,Ram Kishore Agrawal
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2016-05-02
卷期号:16 (10): 825-845
被引量:72
标识
DOI:10.2174/1389557516666160211120835
摘要
Recently, there has been wide interest in compounds containing the oxadiazole scaffold because of their unique chemical structure and their broad spectrum of biological properties. This review provides readers with an overview of the main synthetic methodologies for oxadiazoles and of their broad spectrum of pharmacological activities such as, anti-microbial, anti-fungal activity, antiviral, anti-tubercular, anti-inflammatory, anti-convulsant, anti-angiogenic, anti-proliferative, analgesic, anti-oedema and in alzheimer activity, which were reported over the past years. Keywords: Anti-bacterial, anticonvulsant, antifungal, anti-inflammatory, analgesic, anticancer, oxadiazole.
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