化学
亲核细胞
黄色微球菌
催化作用
反应性(心理学)
抗菌活性
亲核加成
水溶液
组合化学
药物化学
核化学
有机化学
细菌
大肠杆菌
生物化学
医学
遗传学
替代医学
病理
生物
基因
作者
Mohammad Nikpassand,Leila Zare Fekri,Lia Karimian,Mehdi Rassa
出处
期刊:Current Organic Synthesis
[Bentham Science]
日期:2015-05-08
卷期号:12 (3): 358-362
被引量:41
标识
DOI:10.2174/1570179411666141101001949
摘要
A series of new biscoumarins have been synthesized in excellent yields and short reaction times by nucleophilic addition reaction of aldehydes and two equivalents of 4-hydroxycoumarin. The reaction was efficiently promoted by 0.05 g nano Fe3O4 and the catalyst could be recovered easily after the reactions and reused without evident loss of reactivity. All the compounds exhibited strong antibacterial activity towards two Gram positive bacteria, staphylococcus aureus and micrococcus luteus. Keywords: Antibacterial, biscoumarin, heterogeneous, nano Fe3O4, nucleophilic addition.Antibacterial, biscoumarin, heterogeneous, nano Fe3O4, nucleophilic addition.
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