Relationship between LRP5 A1330V polymorphism and hypercholesterolemia

[Objective] To examine the relationship between LRP5 A1330V polymorphism and hypercholesterolemia.[Methods] The genotypes of 346 healthy control and 432 hypercholesterolemia patients were determined by PCR-sequencing.[Results] The allele frequencies of 1330V were 0.22 and 0.14 in hypercholesterolemia patients and in healthy control,respectively.There was significant difference between these two groups(χ2=16.24,P 0.01)and the difference only exist in males,but not females.[Conclusion] A1330V polymorphism in LRP5 gene is a risk factor of hypercholesterolemia in males.