The Characteristics of Porcine Cornea as a Xenograft

角膜 间质细胞 医学 组织相容性 抗体 病理 眼科 抗原 解剖 免疫学 人类白细胞抗原
作者
Hyeon Il Lee,Mee Kum Kim,Jung Hwa Ko,Hyun Ju Lee,Jin Hak Lee,Won Ryang Wee
出处
期刊:Journal of The Korean Ophthalmological Society [Korean Ophthalmological Society]
卷期号:47 (12): 2020-2029 被引量:14
链接
摘要

Purpose: To investigate the feasibility, in terms of both physical and immunological aspects, of using porcine cornea as a xenograft in humans. Methods: Corneal diameter, thickness and axial length were compared in 30 porcine and human control eyes. The histological characteristics and the distribution of the xenonatural antibody were also evaluated. In addition, changes in antigenecity were investigated by cultivating individual corneal cells. Results: The mean values of the porcine corneal diameter (14.2±0.3 mm) and the thickness (867.2±23.8 mm) were larger than those of human, but, on the contrary, the axial length (20.2±0.74 mm) and the refractive power (40.4±0.9D) were not. The lymphocytes existed in the normal porcine limbus, and the distribution of α-gal was confined. However, in the cell culture, the expression of α-gal was prominent in both stromal (39.0±28.4%) and endothelial cells (87.1±4.4%) at the second passage. The expression of class II major histocompatibility antigen was comparable to that of human. Conclusions: Physical, optical, histological, and immunological characteristics suggest the possibility of using porcine cornea as a xenograft in humans.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
FashionBoy应助anna采纳,获得10
1秒前
1秒前
3秒前
大智若愚骨头完成签到,获得积分10
4秒前
4秒前
7秒前
量子星尘发布了新的文献求助10
7秒前
9℃发布了新的文献求助10
7秒前
科研通AI2S应助lm采纳,获得10
8秒前
山谷发布了新的文献求助10
9秒前
感动黄豆发布了新的文献求助10
11秒前
13秒前
14秒前
14秒前
14秒前
16秒前
Owen应助晒太阳的加菲猫采纳,获得10
17秒前
anna发布了新的文献求助10
19秒前
19秒前
wu基督教发布了新的文献求助10
20秒前
21秒前
余南发布了新的文献求助10
22秒前
晒太阳的加菲猫完成签到,获得积分10
22秒前
笑点低诗桃完成签到,获得积分20
23秒前
泡泡脑瓜完成签到,获得积分10
23秒前
25秒前
liche发布了新的文献求助10
25秒前
26秒前
修管子发布了新的文献求助10
26秒前
27秒前
共享精神应助gx采纳,获得10
27秒前
高手完成签到,获得积分20
28秒前
无所谓的啦完成签到,获得积分10
28秒前
ylq关闭了ylq文献求助
29秒前
wu基督教完成签到,获得积分20
29秒前
30秒前
迷人的芹菜完成签到,获得积分10
30秒前
31秒前
Miracle发布了新的文献求助10
31秒前
高手发布了新的文献求助10
32秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105