亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

234 Gastrokine-2 Knockout Mice Display Spontaneous Fundic Atrophy and Hypertrophy With Accelerated Progression Following Helicobacter pylori Infection

幽门螺杆菌 基因剔除小鼠 萎缩 医学 肌肉肥大 幽门螺杆菌感染 螺杆菌感染 病理 胃肠病学 内科学 受体
作者
Trevelyan R. Menheniott,Bayzar Kurklu,Heather V. Chalinor,Yok Teng Chionh,Philip Sutton,Louise M. Judd,Andrew S. Giraud
出处
期刊:Gastroenterology [Elsevier BV]
卷期号:142 (5): S-57
标识
DOI:10.1016/s0016-5085(12)60223-6
摘要

control) was added instead on the other day.Blood glucose, serum insulin, and plasma glucagon were measured from before until 240 min after ingestion of the test meal.Plasma levels of two incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), were measured until 120 min after the meal.Gastric emptying was assessed over 240 min with a 13C acetate breath test (Breath ID System, Exalenz Bioscience Ltd., Israel).Postprandial dyspeptic symptoms were assessed on a visual analogue scale.Results: The insulin peak occurred significantly earlier with MSG.Postprandial glucose was reduced by MSG, and the decrease was significant at 30 min (58.8 ± 4.4 mg/dl with MSG vs. 68.2± 4.3 mg/dl with NaCl, p=0.045 at 30 min postprandially; 53.6 ± 6.1 mg/dl vs. 66.4 ± 6.8 mg/dl, P=0.080 at 45 min).The glucagon level recovered to baseline by 120 min after the meal containing MSG.In contrast, it was still suppressed at 120 min after the meal containing NaCl.However, the area under the concentration versus time curve from 0 to 240 min (AUC (0-240)) for glucose, insulin, or glucagon was not altered by MSG.Plasma GLP-1 was significantly higher at 30 min after the meal containing MSG (58.1 ± 15.8 pmol/L with MSG vs. 13.4 ± 15.8 pmol/L with NaCl, p=0.035).Plasma GLP-1 reached its peak rapidly at 30 min postprandially with MSG, whereas it increased gradually after the meal with NaCl.The half gastric emptying time was not altered by MSG and dyspeptic symptoms were not affected by MSG.Conclusion: MSG induces a more rapid insulin response with improvement of postprandial glycemia and faster recovery of glucagon after intake of a lipid-containing liquid meal.These effects were not associated with a change of gastric emptying, but possibly with increased GLP-1 secretion.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
优美的谷完成签到,获得积分10
刚刚
1秒前
哈哈完成签到 ,获得积分10
1秒前
Hshi完成签到 ,获得积分10
6秒前
Alex完成签到,获得积分0
7秒前
安安完成签到,获得积分10
19秒前
欧阳完成签到 ,获得积分10
26秒前
cherlie应助带虾的烧麦采纳,获得10
35秒前
Ava应助科研通管家采纳,获得10
39秒前
39秒前
骆十八完成签到,获得积分10
43秒前
狸宝的小果子完成签到 ,获得积分10
44秒前
wanci应助义气的蝴蝶采纳,获得10
46秒前
Xiaowen完成签到,获得积分10
48秒前
酷炫的红牛完成签到,获得积分10
50秒前
jll完成签到 ,获得积分10
50秒前
逮劳完成签到 ,获得积分10
58秒前
维维完成签到 ,获得积分10
1分钟前
隐形曼青应助Xiaowen采纳,获得10
1分钟前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
WittingGU完成签到,获得积分0
1分钟前
kdjm688发布了新的文献求助30
1分钟前
1分钟前
yujie完成签到,获得积分10
1分钟前
1分钟前
思源应助孙孙采纳,获得50
1分钟前
1分钟前
1分钟前
1分钟前
一杆长空发布了新的文献求助10
2分钟前
2分钟前
Djnsbj发布了新的文献求助10
2分钟前
孙孙发布了新的文献求助50
2分钟前
2分钟前
2分钟前
2分钟前
123发布了新的文献求助20
2分钟前
科目三应助lan采纳,获得10
2分钟前
临水思长发布了新的文献求助10
2分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976608
求助须知:如何正确求助?哪些是违规求助? 3520700
关于积分的说明 11204542
捐赠科研通 3257350
什么是DOI,文献DOI怎么找? 1798716
邀请新用户注册赠送积分活动 877881
科研通“疑难数据库(出版商)”最低求助积分说明 806613