神经化学
神经科学
神经退行性变
嗅觉
认知
嗅觉系统
嗅球
心理学
抗抑郁药
生物
内科学
医学
海马体
中枢神经系统
疾病
作者
Erik Hendriksen,S. Mechiel Korte,Berend Olivier,Ronald S. Oosting
标识
DOI:10.1016/j.ejphar.2014.10.033
摘要
Olfactory bulbectomy (OBX), the surgical removal of the olfactory bulbs, lead, both in mice and rats, to a specific set of behavioral changes in social behavior, cognitive function and activity. The latter is often used as a readout measure to predict antidepressant effects of new compounds. More recently, the model is used to study neurodegeneration and the associated cognitive decline. Although most of the OBX-induced behavioral and neurochemical changes seen in mice and rats are very similar, there are also some remarkable differences. For instance, OBX has different effects on BDNF and the 5-HT2c receptor of these two species. These species differ also in how they respond to certain treatments after OBX. In this review we describe these species-specific differences and discuss what they may mean in terms of translational value.
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