栀子花
环烯醚萜
化学
茜草科
糖苷
单萜
立体化学
萜类
抑制性突触后电位
传统医学
植物
生物化学
生物
医学
病理
神经科学
替代医学
作者
Toshihiro Akihisa,Kensuke Watanabe,Ayako Yamamoto,Jie Zhang,Masahiro Matsumoto,Makoto Fukatsu
标识
DOI:10.1002/cbdv.201200030
摘要
A new iridoid glycoside, 10-O-(4"-O-methylsuccinoyl)geniposide (7), and two new pyronane glycosides, jasminosides Q and R (13 and 14, resp.), along with nine known iridoid glycosides, 1-6 and 8-10, and two known pyronane glycosides, 11 and 12, were isolated from a MeOH extract of Gardeniae Fructus, the dried ripe fruit of Gardenia jasminoides (Rubiaceae). The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses and comparison with literature. Upon evaluation of compounds 1-14 on the melanogenesis in B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), three compounds, i.e., 6-O-p-coumaroylgeniposide (3), 7, and 6'-O-sinapoyljasminoside (12), exhibited inhibitory effects with 21.6-41.0 and 37.5-47.7% reduction of melanin content at 30 and 50 μM, respectively, with almost no toxicity to the cells (83.7-106.1% of cell viability at 50 μM).
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