金黄色葡萄球菌
生物
肽聚糖
微生物学
生物膜
毒力
病菌
逃避(道德)
免疫系统
人口
细胞壁
细胞粘附
粘附
细菌
细胞
免疫学
基因
化学
生物化学
遗传学
人口学
有机化学
社会学
作者
Timothy J. Foster,Joan A. Geoghegan,Vannakambadi K. Ganesh,Magnus Höök
摘要
Staphylococcus aureusis an important human pathogen that can cause invasive, potentially fatal infections.S. aureus expresses several virulence factors, which include cell wall-anchored surface proteins. Here, Foster and colleagues review the structural characteristics and functions of these proteins and how this knowledge can be used to combat S. aureusinfection. Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. Structural and functional analysis has identified four distinct classes of surface proteins, of which microbial surface component recognizing adhesive matrix molecules (MSCRAMMs) are the largest class. These surface proteins have numerous functions, including adhesion to and invasion of host cells and tissues, evasion of immune responses and biofilm formation. Thus, cell wall-anchored proteins are essential virulence factors for the survival of S. aureus in the commensal state and during invasive infections, and targeting them with vaccines could combat S. aureus infections.
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