Antiproliferative p-terphenyl derivatives isolated from the fungus Sarcodon scabripes

AbstractThe ethanol extract of the fungus Sarcodon scabripes collected from north-central British Columbia, Canada, showed strong antiproliferative activity. Bioassay-guided purification using liquid-liquid extraction and Sephadex LH-20 size-exclusion chromatography, followed by HPLC-MS and 1D/2D NMR analyses, led to the isolation of five known compounds; four p-terphenyl (1-4) derivatives and one phenolic aldehyde (5). Compounds 1, 4, and 5 were isolated for the first time from the Sarcodon genus. The cytotoxicity MTT assay showed that compounds 1-5 have antiproliferative activity against human cervical cancer cells (HeLa). For compounds 1-4, this is the first report of their antiproliferative activity against cancer cells. For compound 2, this is the first report on its bioactivity. To our knowledge, this is the first description of the isolation of bioactive constituents from S. scabripes.Display full sizeKeywords: Sarcodon scabripesp-terphenylantiproliferativemushroom AcknowledgmentsWe thank Ms. Linda Tackaberry and Dr. Hugues Massicotte for collecting S. scabripes (CL124).Disclosure statementThe authors declare no conflict of interest.Additional informationFundingThis research was funded by an NSERC Discovery Grant (227158), a Canada Foundation for Innovation Grant (34711), and a BC Knowledge Development Fund (103970) to C.H.L.